User profiles for S. Janes

Sam Janes

University College London
Verified email at ucl.ac.uk
Cited by 22809

Elective surgery after acute diverticulitis

S Janes, A Meagher, FA Frizelle - Journal of British Surgery, 2005 - academic.oup.com
Background Diverticulitis is a common condition. Practice guidelines from many organizations
recommend bowel resection after two attacks. The evidence for such a recommendation is …

Perspectives on the treatment of malignant pleural mesothelioma

SM Janes, D Alrifai, DA Fennell - New England Journal of …, 2021 - Mass Medical Soc
Mesothelioma Most mesotheliomas originate in the pleura and are due to asbestos exposure.
The incidence is decreasing somewhat with asbestos remediation, but mortality remains …

Epidermal stem cells

SM Janes, S Lowell, C Hutter - … of Pathology: A Journal of the …, 2002 - Wiley Online Library
The clinical implications of understanding epidermal stem cell biology abound. Thousands
of burns victims across the world have benefited from early research into the proliferation of …

[HTML][HTML] Tracking the evolution of non–small-cell lung cancer

…, N Panagiotopoulos, SM Janes… - … England Journal of …, 2017 - Mass Medical Soc
Background Among patients with non–small-cell lung cancer (NSCLC), data on intratumor
heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. …

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

…, S Kolvekar, N Panagiotopoulos, SM Janes… - Nature, 2017 - nature.com
The early detection of relapse following primary surgery for non-small-cell lung cancer and
the characterization of emerging subclones, which seed metastatic sites, might offer new …

[HTML][HTML] Single-cell multi-omics analysis of the immune response in COVID-19

…, E Kilich, A de Wilton, A Saigal, A Saleh, SM Janes… - Nature medicine, 2021 - nature.com
Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

…, T Voet, P Van Loo, DM Rassl, RC Rintoul, SM Janes… - Science, 2014 - science.org
… The 95% confidence intervals for Fisher’s exact test are indicated. (D and E) Three mutation
types (C>A; C>G and C>T) at all 16 possible trinucleotide contexts for L002 (D) and L008 (E)…

[PDF][PDF] Allele-specific HLA loss and immune escape in lung cancer evolution

…, A Smith, M Aranda, M Novelli, D Oukrif, SM Janes… - Cell, 2017 - cell.com
… We reasoned that, by leveraging the reads that map specifically to an individual’s germline
HLA alleles rather than the human reference genome, it would be possible to accurately deter…

A new redox cofactor in eukaryotic enzymes: 6-hydroxydopa at the active site of bovine serum amine oxidase

SM Janes, D Mu, D Wemmer, AJ Smith, S Kaur… - Science, 1990 - science.org
An active site, cofactor-containing peptide has been obtained in high yield from bovine serum
amine oxidase. Sequencing of this pentapeptide indicates: Leu-Asn-X-Asp-Tyr. Analysis of …

[HTML][HTML] Local and systemic responses to SARS-CoV-2 infection in children and adults

…, P De Coppi, CM Smith, AV Misharin, SM Janes… - Nature, 2022 - nature.com
It is not fully understood why COVID-19 is typically milder in children 1 , 2 – 3 . Here, to examine
the differences between children and adults in their response to SARS-CoV-2 infection, …