Despite substantial progress in reducing the global impact of many non-communicable
diseases, including heart disease and cancer, morbidity and mortality due to chronic respiratory …

Rationale: Eradication and suppression of Pseudomonas aeruginosa is a key priority in national
guidelines for bronchiectasis and is a major focus of drug development and clinical trials…

Introduction International guidelines recommend a severity-based approach to management
in community-acquired pneumonia. CURB65, CRB65 and the Pneumonia Severity Index (…

Background The impact of COVID-19 on physical and mental health and employment after
hospitalisation with acute disease is not well understood. The aim of this study was to …

… Polverino (Spain) and JD Chalmers (UK). The task force included specialists in respiratory
medicine with recognised expertise in the management of patients with lung infections, as …

Rationale: There are no risk stratification tools for morbidity and mortality in bronchiectasis.
Identifying patients at risk of exacerbations, hospital admissions, and mortality is vital for …

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of any publisher or professional medical society. This document has not been endorsed by …

BACKGROUND: C-reactive protein (CRP) is an acute phase protein synthesized by the liver
primarily in response to interleukin-6. Initial studies have suggested that inflammatory …

CT scanning can also aid in identifying an aetiology of bronchiectasis eg Allergic
bronchopulmonary aspergillosis (ABPA), Non-tuberculous mycobacteria (NTM), primary ciliary …

Rationale: The vicious cycle hypothesis of bronchiectasis argues that bacterial colonization
leads to airway inflammation and progressive lung damage. The logical extension of this …